CLARA Project INDRC aims to build a unique Center of Excellence to push the frontier of neurodegeneration research International Neurodegenerative Disorders Research Center, INDRC, submitted a project proposal “CLARA – Center for Artificial Intelligence and Quantum Computing in System Brain Research” to the second round of the European Commission´s call “Teaming for Excellence” to gain almost 43 million EUR for the establishment of the very first interdisciplinary Center of Excellence in the Central and Eastern Europe focused on the next generation of artificial intelligence/machine learning applications and quantum-accelerated supercomputing tools to solve the etiology of neurodegenerative diseases. The ultimate goal of CLARA is to push the frontier of neurodegeneration research, particularly Alzheimer’s disease, identify novel pathways to understand brain architecture/network complexity, and discover new intervention targets that ameliorate neurodegeneration. CLARA is built upon a strong consortium of INDRC as the coordinator (with its affiliated partner VSBTechnical University Ostrava), the Czech Institute of Informatics, Robotics, and Cybernetics of the Czech Technical University in Prague, and the International Clinical Research Center of the St. Anne’s University Hospital, all based in the Czech Republic, with two prominent collaborative European research organizations: Paris Brain Institute (France) and Leibniz Supercomputing Centre of the Bavarian Academy of Sciences and Humanities (Germany). CLARA will provide a unique distributed infrastructure – CLARA Testbed – the very first hybrid computing facility that integrates quantum computing and high-performance computing, together as hybrid computing (HPCQC), with artificial intelligence/machine learning with a clear focus on brain research. CLARA strives to merge dispersed knowledge from different scientific disciplines by providing excellent interdisciplinary research programs and fellowship programs of excellence, opening attractive new positions, and building distributed HPCQC infrastructure and a world-class research community around. The uniqueness of CLARA Center of Excellence was acknowledged by the Director General of the Digitalization and Innovation section of the Czech Ministry of Industry and Trade, the Minister for Science, Research and Innovation of the Czech Republic, as well as renowned international scientists, who provided Letters of Support to CLARA.